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Acomplia (Rimonabant) Review

Miracle appetite supressant that also helps quitting smoking!

Acomplia, known under the generic name Rimonabant, repressent newly developed class of weight loss drugs, that exert their action by blocking the endocannabinoid system. It has appetite suppressing effect. Acomplia wass approved in Europe and Latin America, but it was and is not approved for sale in Unated States.

Acomplia is associated with greater risk of developing mental disorders and suicides. Currently it is withdrawn from the market!
Acomplia - strong appetite suppressant

What is Acomplia used for?


Acomplia is an appetite suppressant and is used for the treatment of obesity and related conditions. During clinical trials Acomplia showed other beneficial effects - it can help with smoking cessation, by curbing nicotine cravings.

Acomplia was originally designed as an adjunct to diet and exercise program for the treatment of obese adults, who also suffer from type 2 diabetes or dyslipidamia (high LDL cholesterol levels). It is very suitable for people with large waist circumference (102 cm in men and 88 cm in women), that had the greatest benefit during the trials.

How it works

Acomplia works by blocking the CB1 receptors in the brain and in peripheral organs important to glucose and fat metabolism - guts, fat tissue, liver and muscles.The CB1 receptor appears to be an integrated component of the networks controlling appetite and food intake in the hypothalamus, the brain structure where is located the main center controlling caloric intake and regulating energy balance.

By blocking this receptors, Acomplia reduces your appetite allowing you to achieve your weight loss goals easily, without cravings and hunger bothering you.

CB1 receptors are part of the endocannabinoid system (ECS), that are turned by marujuana. Stimulation of the ECS is associated with obesity and disregulation of the mechanisms involved in energy balance.Since at least 300 AD, cannabis has been known to stimulate hunger and increase appetite, especially for sweet and palatable food. This effect is mediated by the CB1 receptors. Acomplia blocks them, thus turning it off. The effect is strong appetite suppression.

Acomplia and smoking cessation


Acomplia has been studied by the manufacturer as an aid in qiuting smoking. The study involved over 6,500 volunteers.

How effective is Acomplia


A number of trials had been performed with Acomplia to evaluate the effectiveness and safety of the drug. The volunteers that toke part in the trial had been in three groups - one taking placebo (pill, that doesn't contain the active ingridient), second took 5 mg of Acomplia and the third - 20 mg.

The results showed that the mean weight loss in the  20 mg dose groups was 20 pounds or 9 kg, while the placebo grooup lost only 5 pounds. During treatment waist circumference declined too.

These numbers are easily understanded by the graph:

Acomplia - strong appetite suppressant
Fig.1 Graph comparing the weight loss achieved by placebo, Acomplia - 5mg dose and Acomplia - 20 mg dose. Long-term weight loss achieved with 20mg dose was greater than 5 mg dose.

How much weight you can lose with Acomplia?

During clinical trials Acomplia it was shown that the weight loss that can be achieved is about 5-10% of the initial body weight. For a person weighing 200 pounds means that one can lose about 20 pounds for a year. For initial weight of 250 pounds the weight loss that can be achived is about 25 pounds!

Other health benefits that are associated with the use of Acomplia are:

  • Lowering in tryglycerid levels and HDL levels increased.
  •  Blood sugar levels improvement
  • Reducing the risk from developing cardiovascular disease
  • At 1 year, rimonabant had a beneficial effect high density lipoprotein cholesterol (HDL-C), on systolic blood pressure (SBP), triglycerides and fasting plasma glucose in the diabetic and non-diabetic groups, and glycosylated haemoglobin (HbA1c) in the diabetic group.

Potential side effects and contraindications

Common side effects are nausea, diarrhea, vomiting, dizziness, hypoglycemia, fatigue, and anxiety, depression,  insomnia, dizziness, all of which are generally mild or moderate. This side effects occured in 19% of patients taking Acomplia versus 13% in the placebo group.

One of the great concerns when using Acomplia is the risk of developing depression.

Other contraindications identified by the manufacturer include severe hepatic impairment, severe renal impairment, lactose intolerance, and patients over 75.

Overall, Acomplia has been marketed to be effective method for weight reduction and health improvement. When used under doctor's observation, this medication can cause dramatic health improvement even for severely overweight with, as it was thought - only limited side effects.

It turns out that it was not exactly true.

Soon after Acomplia was approved for European market, numerous press reports and independent studies suggests that side effects were more common and more dangerous. The makers of Acomplia, Sanofi-Aventis, itself has shown than the risk of major depression episodes and siucides is far greater when taking Acomplia.

Where I can Order Acomplia?

Currently Acomplia is off-market. Be aware if someone is trying to sell you Acomplia - it is illegal, it is fake or, if it is real Acomplia, you put yourself at a great risk. Better try some more safe alternative.

We do not advise you to try Acomplia, with or without doctor's approval, becouse of the potentially serious side effects.

Choose safer alternative to Acomplia to fight your cravings by clicking here

Is There Natural Alternatives to Acomplia?

Yes. One of the best natural alternatives is Hoodia Gordonii diet pills, which have strong appetite suppressing potential. Another alternative is Proactol. It is complex weight loss system, that offers other great benefits, besides the appetite suppression.


References:
  1. Van Gaal et al. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet. 2005 Apr 16-22;365(9468):1389-97.
  2. Data presented at the American Diabetes Association's 65th Annual Scientific Sessions on June 12, 2005
  3. Després, J.P. et al. Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. New England Journal of Medicine, November, 16, 2005.
  4. Pi-Sunyer, F. X. et al. Effect of Rimonabant, a Cannabinoid-1 Receptor Blocker, on Weight and Cardiometabolic Risk Factors in Overweight or Obese Patients RIO-North America: A Randomized Controlled Trial. Journal of the American Medical Association, February 15, 2005
  5. Pagotto U. Pasquali R. Fighting obesity and associated risk factors by antagonising cannabinoid type 1 receptors. Lancet. 2005; 365: 1363-64.
  6. Van Gaal LF, Rissanen, AM, Scheen AJ, Ziegler O, Rössner S for the RIO-Europe Study Group. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet. 2005;365: 1389-97.
  7. Marzo V, et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 2001;410:822-825.
  8. http://www.drugs.com/acomplia.html
  9. http://news.bbc.co.uk/2/hi/health/7687311.stm

 

 
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