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Hoodia Gordonii - Appetite Suppressant

Natural and strong appetite suppressant! 

What is Hoodia?

Botanical (Latin) name: Hoodia gordonii
Other names and common misspelings: hoodia cactus, hoodia, xhooba, !khoba, Ghaap,  South African desert cactus, hudea, hudia, hoodea, Bushman's Hat and Queen of the Namib.

Hoodia (pronounced HOO-dee-ah) is a bitter-sweet cactus-like plant that grows primarily inHoodia Gordonii Natural Appetite Suppressant the Kalahari semi-deserts of South Africa, Botswana, Namibia, and Angola. It was used for thousands of years by the San Bushmen people as an appetite suppressant and thirst quencher during their long hunting treks through the desert. 

Other medicinal uses of this plant are for indigestion problems and small infections. 

Hoodia gordonii is a genus of several Hoodia species, but it is the only species that has such strong appetite suppressing potential.

In the last few years, hoodia has been heavily marketed for weight loss and has become immensely popular as an appetite suppressant. Here we will try to clarify this claims and propose the best available Hoodia.

History of Hoodia

The first evidence for Hoodia came from Dutch anthropologist in 1937, who noted that Buchmen people ate Hoodia gordonii during their hunting in the dessert in order to suppress their hunnger and thirst. This was unnoticed for years until 1966 when the scientists from Council for Scientific and Industrial Research (CSIR) in South Africa began studying Hoodia. The laboratory animals, fed with Hoodia lost weight!

So they began further laboratory studyes in order to isolate the active substance. They succeeded in 1977 when they finaly isolated a steroidal glycoside, and named it p57. The patent was given to british pharmaceutical company Phytopharm, which took part in the investigations.

Why there is no weight loss pills containing only the active ingredient? There were attempts to be made. Phytopharm sub-licensed the patent to the pharmaceutical giant Pfizer. They tried to synthetize p57 in laboratory, but it turned out to be too expensive. So they lost interest and returned the patent to Phytopharm.

How Hoodia works?

The evidence for Hoodia effectivenes

The first evidence for its effectiveness is coming from the Bushmen people. For them there is no question if Hoodia was effective. They just know it and chew some Hoodia to suppress appetite.

A growing number of evidence came from the media. Hoodia has wide media coverage in NBC, ABC, CNN, BBC etc. Here is what Leslie Stahl says about her experience with Hoodia in 60 minutes (aired in Nov 2004):

So how did it work? Stahl says she had no after effects - no funny taste in her mouth, no queasy stomach, and no racing heart. She also wasn't hungry all day, even when she would normally have a pang around mealtime. And, she also had no desire to eat or drink the entire day. "I'd have to say it did work," says Stahl.
- Leslie Stahl reporting on CBS News 60 Minutes

Another BBC correspondent, Tom Mangold reported the following after eating Hoodia too:

At about 1800hrs I ate about half a banana size (piece of hoodia gordonii) - and later so did my cameraman. Soon after, we began the four hour drive back to Capetown.
The plant is said to have a feel-good almost aphrodisiac quality, and I have to say, we felt good. But more significantly, we did not even think about food. Our brains really were telling us we were full. It was a magnificent deception.

That’s enough for the media coverage of Hoodia. There are number of such reportings which can be easily found. What is more important is the…

Scientific evidence for the effectiveness of Hoodia?how hoodia works brain

At first it was not clear how Hoodia works to suppress appetite. After some investigation scientists found that active ingredient p57 mimics the effect of glugose on the brain cells.

Normally, when we are eat our glucose levels get high. This is sensed by neurons in the brain. These neurons sens signals to the hypothalamus, area of the brain that controlls appetite and suppress appetite. Your brain says you are full.

What p57 does is to mimic the action of the glucose on the brain. So your brain receives signals that you are full and cuts the curbs for food. Simple and effective, isn’t it? Here is how Phytopharm's Dr Richard Dixey explained how P-57 actually works:

"There is a part of your brain, the hypothalamus. Within that mid-brain there are nerve cells that sense glucose sugar. how hoodia works
When you eat, blood sugar goes up because of the food, these cells start firing and now you are full. What the Hoodia seems to contain is a molecule that is about 10,000 times as active as glucose. It goes to the mid-brain and actually makes those nerve cells fire as if you were full. But you have not eaten. Nor do you want to."

Another excerpt from scientific report:

"Studies conducted at the Council for Scientific and Industrial Research (CSIR, South Africa) identified extracts from Hoodia species, in particular Hoodia pilifera and Hoodia gordonii, as possessing strong appetite suppressant properties.....Compound 1 was tested for its strong appetite suppressant properties ... and the results showed that all doses resulted in a decrease of food consumption over an eight day period and a body mass decrease when compared to the control ... In a comparative study against a fenfluramine control sample, compound 1 resulted in a reduction in food intake over the study period, with a concomitant overall decrease in body weight ..."

What clinical trials has been done?

Phytopharm done a clinical trial with volunteers, that were split into two groups – the first received placebo, the second received the active appetite suppressing ingredient p57. Here are the summarized results:

  • The P57 group had a statistically significant reduction in body fat
  • The P57 group had a statistically significant reduction in caloric intake
  • The P57 had no adverse side effects 
  • On average the P57 group ate about 1,000 calories a day less than those in the control group. To put that in perspective, the average American man consumes about 2,600 calories a day; a woman about 1,900
Another study was made by R. Goldfarb, M.D., medical director of Bucks County Clinical Research. His study was small using a particular brand DEX-L10, brand of Delmar Labs. The participants of the study lost about 10 pounds in 28 day period (median weight loss of 3,3%). The patients also reported that their caloric intake dropped to less than half within a few days. No side effects were reported.

It is clear that Hoodia is effective and strong appetite suppressant, that will help you to:

  • reduce your cravings for food
  • reduce your calorie intake
  • lose weight with ease without feeling hungry all the time
  • no side effects, besides losing weight!

Side effects of Hoodia

Even though Hoodia is an all natural medication, some people may not be recommended to take Hoodia. If you are unsure about Hoodia safety, please talk to your doctor before taking Hoodia, if you have:
  • Diabetes
  • Heart Disease
  • High Blood Pressure
  • Anorexia, Bulimia
  • Plant or health supplement allergies
  • Bleeding or clotting disorder
  • Pregnant or trying to become pregnant or breastfeeding
Although Hoodia safety was established without any doubt, you should not take it if you have any of the listed conditions.

Are all sellers offering real Hoodia extracts?

No. In fact most of the Hoodia sellers are not offering a quality product. In some of the sample, that were tested the active ingredient was in very small quantity. This may be due to the fact, that Hoodia is pretty rare and expensive plant, and it is hard to obtain. According our research only few sellers are licensed and are selling really quality product.

Learn where to obtain the best quality Hoodia products (click here)>>


  1. MacLean DB, Luo LG. "Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside." Brain Research Volume 1020, Issues 1-2 , 10 September 2004, Pages 1-11.
  2. Weighing the Evidence in Diet Ads, US Federal Trade Commission
  3.  Mangold, Tom. "Sampling the Kalahari Hoodia diet". BBC Correspondent, May 30, 2003.
  4.  Stahl, Lesley. "African Plant May Help Fight Fat". CBS News 60 Minutes, November 21, 2004.
  5. An appetite suppressant from Hoodia species.
  6. Phytochemistry. 2007 Oct;68(20):2545-53. Epub 2007 Jul 2.
  7. PMID: 17603088 [PubMed - indexed for MEDLINE]
  8. http://www.webmd.com/diet/guide/hoodia-lots-of-hoopla-little-science
  9. “African plant may help fight fat” @ www.cbsnews.com, accessed 4/15/08
  10. “Hoodia: lose weight without feeling hungry?” @ www.consumerreports.com, pg 49, accessed 4/15/08.
  11. “Hoodia” @ www.wikipedia.com, accessed 4/15/08.
  12. Van Heerden FR. Marthinus Horak R. Maharaj VJ. Vleggaar R. Senabe JV. Gunning PJ. An appetite suppressant from Hoodia species. Phytochemistry. 68(20):2545-53, 2007 Oct.
  13. Wong, W. Hoodia- side effects of hoodia @ www.altmedicine.about.com, accessed 4/16/08.

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