Appetite
suppressants are the most used drugs medications for weight loss.
That is not surprising, as the obesity is a condition that needs long-term treatment in order to
promote and sustain weight loss. Appetite suppressants
have simple and logical mechanism promoting and triggering weight loss
- they make you feel
less hungry, by tricking your appetite and satiety brain centers.
There is two ways by which they exert their effects:
- Reduce
appetite (make you not feel hungry)
- Increase
satiety (make you feel full)
These effects are achieved by their action on various brain
neurotransmitter pathways, that control appetite and satiety. In the
text thatfollows we briefly describe the different mechanism for the strong
appetite suppressants.
Appetite suppressants that mimic
noradrenaline action (sympathomimetics)
Anorectic drugs that mimic
noradrenaline effect in the central nervous system act as stimulants. It
stimulates the central nervous system (nerves and brain), which
increases your heart rate and blood pressure and decreases your
appetite. They act like amphetamines (speed) and most are its
derivatives.
They work by blocking the reuptake or enhancing the release of
noradrenaline, thus increasing its levels in the brain and increasing
its effect on neurons. This results in feeling of fullness and
decreased feeling of hunger. Such drugs are amphetamines (non-available
of the serious side-effects and development of tolerance), Phentermine, Mazindol
and Diethylpropion, phendimetrazine.
A
fig showing the release of norepinephrine (NE) in the neurons and exact
place where appetite suppressants do their job.
Appetite suppressants that mimic serotonine
action
They act by increasing the release of serotonine, inhibiting its
reuptake,or both. Serotonin plays a vital role in many brain
functions like mood,memory, sleep, pain perception, sexual desire and
appetite. Such medications are Fenfluramine and
Dexfenfluramine,
which are currently withdrawn from the market, because of potentially
life-threatening side effects. Serotitnergic agents, that are currently
approved, are now used for the treatment of depression and
obsessive-compulsive disorders. They also may promote weight loss
during treatment, but they failed to promote long-term weight loss.
Appetite suppressants that have mixed
norepinephrine-serotonine action
They act on several neurotransmitter
system at the same time - inhibits the reuptake of serotonine,
noradrenaline and dopamine. Such medication is Subitramine (known
under the names Meridia for US
market, and
Reductil
for European market). It acts in the area of the brain that signals
fullness
(satiety) - it just tells your brain that you are full. Fullness is
your signal to stop eating, and having this signal means that you may
feel satisfied with less food. It has also mild thermogenic effects,
which attenuates the usual decline in metabolic rate with weight loss.
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Appetite suppressants that act on
endocannabinoid system
These are newly developed appetite suppressants, that act on canabinoid
system. Canabinoid system has many functions in the body and
contributes to mood, control of appetite energy balance and body
weight. The canabinoid neurotransmitter system is the main target of
cannabis (THC). It was observed that people using marijuana ate more
high-fat and high-sweet foods, and felt hungry. The canabinoid system
had been researched for many years and number of new medications had
been developed. Rimonabant
(Acomplia) is a recently developed appetite
suppressing drug that is a selective blocker of
the canabinoid
receptor CB1. According studies it is highly effective
drug, that has
fewer side effects. Other benefits of Rimonabant is that it promotes
quitting smoking.
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P57 glicosides and Hoodia
Glycosides are substances that are found in many plant species and have
various effects. Hoodia Gordonii
is the only known plant that is known
to produce glycosides that suppress appetite. The evidence of the
effectiveness of Hoodia are known from eons - Bushmen people used
Hoodia Gordonii
cactus to suppres their appetite during their long treks along the
dessert. The appetite suppressing glycosides are named p57, and they
mimic the effect of glucose on the brain. They actually fool your
brain that you are full.
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HOODIA>>
Proactol - gives you fullnes and suppress
appetite
Proactol
is unique weight loss pill. It is made of organic fiber complex,
NeoPuntia, that slows emptying your stomach, thus way giving you the
sense of fullness and suppressing appetite. But that is not all -
Proactol also binds digested fats, preventing them from being absorbed.
Thus way acting as a fat blocker.
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CAN GIVE YOU SLIMMER APPEARENCE>>
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